Programação
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Este ano, excepcionalmente em função da Coronavirus Disease-2019 (COVID- 19), mudaremos nosso formato para a Disciplina.
Não teremos as aulas práticas que, a meu ver, constituem o ponto alto da disciplina, mas teremos uma abordagem bem legal e integrada sobre os sistema cardiovascular, com excelentes professores e pesquisadores
Teremos uma mistura de estilos: aulas/palestras gravadas que vocês poderão ver a qualquer tempo; aulas/palestras on-line em tempo real e grupos de discussão.
A regulação do sistema cardiovascular será abordada em vários níveis, desde os mecanismos centrais e sistêmicos que regulam, tanto a curto quanto a longo prazo, o débito cardíaco, a resistência vascular periférica e, consequentemente, a pressão arterial (mecanismos centrais, hormonais, rins, sistema imune), até os mecanismos locais de controle do fluxo sanguíneo e a resistência vascular periférica (endotélio, PVAT, resposta miogênica).
Também conversaremos sobre situações especificas, tanto fisiológicas (exercício físico, estresse, sexo e hormônios sexuais) como patológicas (hipertensão arterial, alcoolismo, obesidade, aterosclerose) que impactam diretamente a função cardiovascular.
Para cada um dos temas, os professores indicaram um artigo de revisão e 2 artigos (1 histórico e outro recente) com dados originais sobre o tema.
Idealmente, vocês deveriam ler estes artigos antes das palestras / aulas, para maior aproveitamento.
AbraçosRita Tostes
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1. Aspectos Fisiológicos do Sistema Cardiovascular
Prof. Rubens Fazan, FMRP-USP
https://meet.google.com/rcd-veak-yoz?hs=122
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1. Aspectos Fisiológicos do Sistema Cardiovascular
Prof. Rubens Fazan, FMRP-USP
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2. Os rins e a modulação da função cardiovascular
Profa. Maria Oliveira de Souza, ICB-USP
https://meet.google.com/isb-wctk-rki?hs=122
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2. Os rins e a modulação da função cardiovascular – Profa. Maria Oliveira Souza
2.1. Danziger J, Hoenig MP. The Role of the Kidney in Disorders of Volume: Core Curriculum 2016. Am J Kidney Dis. 68(5):808-816, 2016.
2.2. Ellison DH. Clinical Pharmacology in Diuretic Use. CJASN 14: 1248–1257, 2019. doi: https://doi.org/10.2215/CJN.09630818
2.3. Kamejima S, Tatsumi N, Anraku A, Suzuki H, Ohkido I, Yokoo T, Okabe M. Gcm1 is involved in cell proliferation and fibrosis during kidney regeneration after ischemia– reperfusion injury. Scientific Reports 9:7883, 2019. https://doi.org/10.1038/s41598-019-44161-y
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2. Os rins e a modulação da função cardiovascular
Profa. Maria Oliveira de Souza, ICB-USP
https://meet.google.com/isb-wctk-rki?hs=122
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3. Mecanismos centrais que regulam o sistema cardiovascular
Dr. Mateus Amorim, FORP-USP
https://meet.google.com/mbq-zhqa-ebd?hs=122
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3. Mecanismos centrais que regulam o sistema cardiovascular – Dr. Mateus Amorim
3.1. Dampney RAL, Coleman MJ, Fontes MAP, Hirooka Y, Horiuchi J, Li YW, et al. Central mechanisms underlying short- and long-term regulation of the cardiovascular system. Clin Exp Pharmacol. Physiol. 2002;29(4):261–8.
3.2. Neurogenic hypertension in the rat. Krieger EM. Circ Res. 1964 dec;15:511-21
3.3. Amorim, M. R. et al. Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation. J. Neuroinflammation 16, 125 (2019)
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3. Mecanismos centrais que regulam o sistema cardiovascular
Dr. Mateus Amorim, FORP-USP
https://meet.google.com/mbq-zhqa-ebd?hs=122
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4. O sistema renina-angiotensina-aldosterona
Prof. Thiago Bruder, University of Pittsburgh
https://meet.google.com/aew-xzqc-juf?hs=122
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4. O sistema renina-angiotensina-aldosterona – Prof. Thiago Bruder
4.1. Williams JS, Williams GH. 50th anniversary of aldosterone. J Clin Endocrinol Metab. 88(6):2364-72, 2003.
4.2. Tait SA, Tait JF, Coghlan JP. The discovery, isolation and identification of aldosterone: reflections on emerging regulation and function. Mol Cell Endocrinol. 217(1-2):1-21, 2004.
4.3. Bruder-Nascimento T, Ferreira NS, Zanotto CZ, Ramalho F, Pequeno IO, Olivon VC, Neves KB, Alves-Lopes R, Campos E, Silva CA, Fazan R, Carlos D, Mestriner FL, Prado D, Pereira FV, Braga T, Luiz JP, Cau SB, Elias PC, Moreira AC, Câmara NO, Zamboni DS, Alves-Filho JC, Tostes RC. NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage. Circulation. 134(23):1866-1880, 2016.
4.4. McCurley A, Pires PW, Bender SB, Aronovitz M, Zhao MJ, Metzger D, Chambon P, Hill MA, Dorrance AM, Mendelsohn ME, Jaffe IZ. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med. 18(9):1429-33, 2012.
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4. O sistema renina-angiotensina-aldosterona
Prof. Thiago Bruder, University of Pittsburgh
https://meet.google.com/aew-xzqc-juf?hs=122
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5. Técnicas utilizadas para o estudo da função vascular
Profa. Luciana Rossoni, ICB-USP
https://meet.google.com/ojy-bhjq-gnn?hs=122
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5. Técnicas utilizadas para o estudo da função vascular – Profa. Luciana Rossoni
5.1. Aaron Stupica, Keshari Thakali. Studying Smooth and Striated Muscle Function Using Advanced Tissue Bath Systems
5.2. Éric Thorin, Gerry Herrera. Studying Flow Mediated Responses in Isolated Vasculature.
5.3. Raj Khirasaria. Isolated Tissue Preparations.
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5. Técnicas utilizadas para o estudo da função vascular
Profa. Luciana Rossoni, ICB-USP
https://meet.google.com/ojy-bhjq-gnn?hs=122
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6. Fundamentos básicos de Farmacologia
Prof. Fernando Carneiro, FMRP-USP
https://meet.google.com/sqh-hiwt-nhw?hs=122
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6. Fundamentos básicos de Farmacologia – Prof. Fernando Carneiro
6.1. Langley JN. On the reaction of cells and of nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari. J Physiol. 1905 Dec 30;33(4-5):374-413.
6.2. Van Rossum JM, Van Den Brink FG. Cumulative dose-response curves. I. Introduction to the technique. Arch Int Pharmacodyn 143:240-246, 1963.
6.3. Van Rossum JM. Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Arch Int Pharmacodyn Ther. 143:299–330, 1963.
6.4. EJ Ariëns, AM Simonis. A molecular basis for drug action. J. Pharm. Pharmacol., 16, 137-157, 1964.
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6. Fundamentos básicos de Farmacologia
Prof. Fernando Carneiro, FMRP-USP
https://meet.google.com/sqh-hiwt-nhw?hs=122
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7. Endotélio e função vascular
Profa. Cristina Antoniali, FOA-UNESP Araçatuba
https://meet.google.com/ubi-mghd-sni?hs=122
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7. Endotélio e função vascular – Profa. Cristina Antoniali
7.1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980; 288(5789):373-6.
7.2. Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524, 1987.
7.3. Graton ME, Potje SR, Troiano JA, Vale GT, Perassa LA, Nakamune ACMS, Tirapelli CR, Bendhack LM, Antoniali C. Apocynin alters redox signaling in conductance and resistance vessels of spontaneously hypertensive rats. Free Radic Biol Med. 134:53-63, 2019. doi: 10.1016/j.freeradbiomed.2018.12.026.
7.4. Paul M. Vanhoutte, Yingzi Zhao, Aimin Xu, Susan W.S. Leung. Thirty Years of Saying NO. Sources, fate, actions, and misfortunes of the endothelium-derived vasodilator mediator. Circ Res. 119:375-396, 2016. doi: 10.1161/circresaha.116.306531.
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7. Endotélio e função vascular
Profa. Cristina Antoniali, FO-UNESP Araçatuba
https://meet.google.com/ubi-mghd-sni?hs=122
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8. Tecido adiposo perivascular (PVAT) e função vascular
Prof. Eliana Akamine, ICB-USP
https://meet.google.com/gdg-abez-nsf?hs=122
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8. Tecido adiposo perivascular (PVAT) e função vascular – Profa. Eliana Akamine
8.1. L Chang, MT Garcia-Barrio, YE Chen. Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 40, 2020. DOI: 10.1161/ATVBAHA.120.312464
8.2. M Lohn, G Dubrovska, B Lauterbach, FC Luft, M Gollasch, AM Sharma. Periadventitial fat releases a vascular relaxing factor. The FASEB Journal 16:1057-1063, 2002.
8.3. RK Kumar, Y Jin, SW Watts, CE Rockwell. Naïve, Regulatory, Activated, and Memory Immune Cells Co-exist in PVATs That Are Comparable in Density to Non-PVAT Fats in Health. Frontiers in Physiology 11(58), 2020. doi: 10.3389/fphys.2020.00058
8.4. AH Turaihi, EH Serné, CFM Moltho, JJ Koning, J Knol, HW Niessen, MJTH Goumans, EM van Poelgeest, JS Yudkin, YM Smulders, CR Jimenez, VWM van Hinsbergh, EC Eringa. Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression, and Glucose Uptake in Muscle Through Adipomuscular Arterioles. Diabetes 69(4): 603-613, 2020.
https://doi.org/10.2337/db18-1066
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8. Tecido adiposo perivascular (PVAT) e função vascular
Prof. Eliana Akamine, ICB-USP
https://meet.google.com/gdg-abez-nsf?hs=122
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9. Mecanismos que controlam os processos de contração-relaxamento nas células musculares lisas vasculares
9. Mecanismos que controlam os processos de contração-relaxamento nas células musculares lisas vasculares
Profa. Rita C Tostes, FMRP-USP
https://meet.google.com/mdg-zjxp-gsf?hs=122
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9. Mecanismos que controlam os processos de contração-relaxamento nas CMLV – Prof. Rita Tostes
9.1. Ringer S. A further contribution regarding the influence of the different constituents of the blood on the contraction of the heart. J Physiol 1883; 4, 29–42.
9.2. Durbin RP, Jenkinson DH. The calcium dependence of tension development in depolarized smooth muscle. J Physiol. 1961 Jun;157:90-6.
9.3. DeFeo TT, Morgan KG. Calcium-force relationships as detected with aequorin in two different vascular smooth muscles of the ferret. J Physiol. 1985; 369:269-82.
9.4. Tostes RC, Leite R, Webb RC. Vascular smooth muscle contraction and relaxation. In: Hypertension Primer. Joseph L. Izzo, Domenic A. Sica, Henry Richard Black - 2008 - Medical
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9. Mecanismos que controlam os processos de contração-relaxamento nas células musculares lisas vasculares
Profa. Rita C Tostes, FMRP-USP
https://meet.google.com/mdg-zjxp-gsf?hs=122
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10. Resposta miogênica
Profa. Luciana Rossoni, ICB-USP
https://meet.google.com/ipe-mype-xzi?hs=122
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10. Resposta miogênica – Profa. Luciana Rossoni
10.1. Davis MJm, Hill MA. Signaling Mechanisms Underlying the Vascular Myogenic Response. Physiological Reviews 79(2): 387-423, 1999.
10.2. Raina H, Ella SR, Hill. MA. Decreased activity of the smooth muscle Na+/Ca2+ exchanger impairs arteriolar myogenic reactivity. J Physiol 586(6): 1669–1681, 2008.
10.3. Paula SM, Couto GK, Fontes MT, Costa SK, Negrão CE, Mill JG, Rossoni LV. Exercise training restores the myogenic response in skeletal muscle resistance arteries and corrects peripheral edema in rats with heart failure. Am J Physiol Heart Circ Physiol 317: H87–H96, 2019.
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10. Resposta miogênica
Profa. Luciana Rossoni, ICB-USP
https://meet.google.com/ipe-mype-xzi?hs=122
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11. Exercício físico na Insuficiência Cardíaca
Profa. Patrícia C Brum, EEFE-USP
https://meet.google.com/pda-zotv-vfo?hs=122
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11. Exercício Físico na Insuficiência Cardíaca – Profa. Patrícia Brum
11.1. Arnold M. Katz. The “Modern” View of Heart Failure How Did We Get Here? Circ Heart Fail. 1:63-71, 2008. DOI: 10.1161/CIRCHEARTFAILURE.108.772756
11.2. PC Brum, AVN Bacurau, A Medeiros, JCB Ferreira, AS Vanzelli, CE Negrão. Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function. Braz J Med Biol Res, September 44(9) 827-835, 2011. doi: 10.1590/S0100-879X2011007500075
11.3. JC Camposa, BB Queliconic, LHM Bozia, LRG Becharaa, PMM Dourado, AM Andres, PR Jannig, KMS Gomes, VO Zambelli, C Rocha-Resendeg, S Guatimosim, PC Brume, D Mochly-Rosenh, RA Gottlieb, AJ Kowaltowskic, JCB Ferreira. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. Autophagy 13(8): 1304–1317, 2017.
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11. Exercício físico na Insuficiência Cardíaca
Profa. Patrícia C Brum, EEFE-USP
https://meet.google.com/pda-zotv-vfo?hs=122
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12. Ativação do sistema cardiovascular em situações de estresse
Prof. Carlos Crestani, FCF-UNESP Araraquara
https://meet.google.com/sib-ymoo-sco?hs=122
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12. Ativação do sistema cardiovascular em situações de estresse – Prof. Carlos Crestani
12.1. Crestani CC. Emotional Stress and Cardiovascular Complications in Animal Models: A Review of the Influence of Stress Type. Front Physiol. 7:251, 2016.
12.2. Schadt JC, Hasser EM. Hemodynamic effects of acute stressors in the conscious rabbit. Am J Physiol. 274(3):R814-21, 1998.
12.3. Dos Reis DG, Fortaleza EA, Tavares RF, Corrêa FM. Role of the autonomic nervous system and baroreflex in stress-evoked cardiovascular responses in rats. Stress. 17(4):362-72, 2014.
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12. Ativação do sistema cardiovascular em situações de estresse
Prof. Carlos Crestani, FCF-UNESP Araraquara
https://meet.google.com/sib-ymoo-sco?hs=122
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13. Diferenças sexuais, hormônios sexuais e o sistema cardiovascular
Dr. Tiago J Costa, FMRP-USP
https://meet.google.com/abh-jjkd-dit?hs=122
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13. Diferenças sexuais, hormônios sexuais e o sistema cardiovascular – Dr. Tiago Costa
13.1. Costa, T. J.; Echem, C; Colli, LG; Akamine, EH; Dantas AP; Carvalho, MHC. Characteristics of Endothelium in both sexes. In: Protásio da Luz; Petter Libby; Francisco Laurindo; Antonio Chagas. (Org.). Endothelium and Cardiovascular Diseases. 1ed.: Academic Press, 2017, v. 1, p. 1-800.
13.2. Fortes ZB, Nigro D, Scivolleto R, Carvalho MHC. Influence of sex on the reactivity to endothelin-1 and noradrenaline in spontaneously hypertensive rats. Clin Exp Hypertens (Theory and practice). A13(5):807-816, 1991.
13.3. AlSiraj Y, Chen X, Thatcher SE, Temel RE, Cai L, Blalock E, Katz W, Ali HM, Petriello M, Deng P, Morris AJ, Wang X, Lusis AJ, Arnold AP, Reue K, Thompson K, Tso P, Cassis LA. XX sex chromosome complement promotes atherosclerosis in mice. Nature Communications | (2019)10:2631 | https://doi.org/10.1038/s41467-019-10462-z
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13. Diferenças sexuais, hormônios sexuais e o sistema cardiovascular
Dr. Tiago J Costa, FMRP-USP
https://meet.google.com/abh-jjkd-dit?hs=122
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14. Sexo, Função erétil e sistema cardiovascular
Prof. Fernando Carneiro, FMRP-USP
https://meet.google.com/rfu-zvuu-bnh?hs=122
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14. Sexo, Função erétil e sistema cardiovascular – Fernando Carneiro
14.1. G Corona, G Rastrelli, AM Isidori, R Pivonello, C Bettocchi, Y Reisman, A Sforza, M Maggi. Erectile dysfunction and cardiovascular risk: a review of current findings. Expert Review of Cardiovascular Therapy. DOI: 10.1080/14779072.2020.1745632
14.2. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 151(1):54-61, 1994.
14.3. Montorsi P, Ravagnani PM, Galli S, Rotatori F, Veglia F, Briganti A, Salonia A, Deh`o F, Rigatti P, Montorsi F, Fiorentini C. Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. European Heart Journal 27: 2632–2639, 2006. doi:10.1093/eurheartj/ehl142.
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14. Sexo, Função erétil e sistema cardiovascular
Prof. Fernando Carneiro, FMRP-USP
https://meet.google.com/rfu-zvuu-bnh?hs=122
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15. O Sistema imune e o sistema cardiovascular
Prof. Stefany Cau, ICB-UFMG
https://meet.google.com/oui-qhkt-wgp?hs=122
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15. O Sistema imune e o sistema cardiovascular - Prof. Stefany Cau
15.1. Bomfim GF, Cau SBA, Bruno AS, Fedoce AG, Carneiro FS. Hypertension: a new treatment for an old disease? Targeting the immune system. Br J Pharmacol. 2019 Jun;176(12):2028-2048. doi: 10.1111/bph.14436.
15.2. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, Goronzy J, Weyand C, Harrison DG. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007 Oct 1;204(10):2449-60.
15.3. Xiao L, do Carmo LS, Foss JD, Chen W, Harrison DG. Sympathetic Enhancement of Memory T-Cell Homing and Hypertension Sensitization. Circ Res. 2020 Mar 13;126(6):708-721. doi: 10.1161/CIRCRESAHA.119.314758.
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15. O Sistema imune e o sistema cardiovascular
Prof. Stefany Cau, ICB-UFMG
https://meet.google.com/oui-qhkt-wgp?hs=122
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16. O sistema respiratório e o sistema cardiovascular
Dr. Mateus Amorim, FORP-USP
https://meet.google.com/kxx-cgvw-fbk?hs=122
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16. O sistema respiratório e o sistema cardiovascular – Dr. Mateus Amorim
16.1. Adrian ED, Bronk DW, Phillips G. Discharges in mammalian sympathetic nerves. J Physiol. 1932;74(2):115–33.
16.2. Zoccal DB, Simms AE, Bonagamba LGH, Braga VA, Pickering AE, Paton JFR, et al. Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity. J Physiol. 2008;586(13):3253–65.
16.3. Amorim MR, Souza GMPR, Machado, BH. Possible Breathing Influences on the Control of Arterial Pressure After Sino-aortic Denervation in Rats. Current Hypertension Reports (2018) 20:2.
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16. O sistema respiratório e o sistema cardiovascular
Dr. Mateus Amorim, FORP-USP
https://meet.google.com/kxx-cgvw-fbk?hs=122
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17. Álcool e o sistema cardiovascular
Prof. Carlos Renato Tirapelli, EERP-USP
https://meet.google.com/xua-zqpj-uaa?hs=122
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17. Álcool e o sistema cardiovascular- Prof. Carlos Tirapelli
17.1. Klatsky AL. Alcohol and cardiovascular diseases: where do we stand today? J Intern Med. 278(3):238-50, 2015. doi: 10.1111/joim.12390.
17.2. Chan TCK, Wall RA, Sutter MC. Chronic Ethanol Consumption, Stress, and Hypertension. Hypertension 7: 519-524, 1985.
17.3. Do Vale GT, Simplicio JA, Gonzaga NA, Yokota R, Ribeiro AA, Casarini DE, de Martinis BS, Tirapelli CR. Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol. Atherosclerosis 274:67-76, 2018.
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17. Álcool e o sistema cardiovascular
Prof. Carlos Renato Tirapelli, EERP-USP
https://meet.google.com/xua-zqpj-uaa?hs=122
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18. Obesidade e o sistema cardiovascular
Prof. Rafael Menezes, Univ. Fed Jataí
https://meet.google.com/ewp-pshv-zsb?hs=122
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18. Obesidade e o sistema cardiovascular - Rafael
18.1. Ortega FB, Lavie CJ, Blair SN. Obesity and cardiovascular disease. Circulation Research, 118(11): 1752-1770, 2016.
18.2. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science, 259(5091): 87-91, 1993.
18.3. Da Costa, Rafael Menezes et al. TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice. Cardiovascular Diabetology, 15(1): 119, 2016.
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18. Obesidade e o sistema cardiovascular
Prof. Rafael Menezes, Univ. Fed Jataí
https://meet.google.com/ewp-pshv-zsb?hs=122
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19. Aterosclerose
Dra. Josiane Fernandes Silva, FMRP-USP
https://meet.google.com/rpa-gvga-gyp?hs=122
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19. Aterosclerose - Dra. Josiane Fernandes
19.1. P Libby, JE Buring, L Badimon, GK Hansson, J Deanfield, MS Bittencourt, L Tokgözoğlu, EF Lewis. Atherosclerosis. Nat Rev Dis 5(1):56, 2019. doi: 10.1038/s41572-019-0106-z.
19.2. SH Zhang, RL Reddick, JA Piedrahita, N Maeda. Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E. Science 258(5081): 468-471, 1992.
19.3. J Hung, JP Scanlon, AD Mahmoud, J Rodor, M Ballantyne, MAC Fontaine, L Temmerman, J Kaczynski, KL Connor, R Bhushan, EAL Biessen, DE Newby, JC Sluimer, AH Baker. Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON).Arteriosclerosis, Thrombosis, and Vascular Biology. 40:697–713, 2020.
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19. Aterosclerose
Dra. Josiane Fernandes Silva, FMRP-USP
https://meet.google.com/rpa-gvga-gyp?hs=122
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20. Hipertensão Arterial
Profa. Rita C Tostes, FMRP-USP
https://meet.google.com/ooe-hxxj-vxd?hs=122
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20. Hipertensão Arterial – Profa. Rita Tostes
20.1. Theodora Szasz & Rita C. Tostes. Vascular Smooth Muscle Function in Hypertension. Colloquium Series on Integrated Systems Physiology: From Molecule to Function to Disease. Series Editors: D. Neil Granger & Joey Granger. ISBN: 9781615046843, PDF ISBN: 9781615046850. Morgan & Claypool Publishers. 2017, 104 pages.
20.2. JR Petrie, TJ Guzik, RM Touyz. Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms Canadian Journal of Cardiology 34, 575e584, 2018.
20.3. Holloway ET, Bohr DF. Reactivity of vascular smooth muscle in hypertensive rats. Circ Res. 33(6):678-85, 1973.
20.4. Berecek KH, Bohr DF. Structural and functional changes in vascular resistance and reactivity in the deoxycorticosterone acetate (DOCA)-hypertensive pig. Circ Res. 40(5 Suppl 1):I146-52, 1977.
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20. Hipertensão Arterial
Profa. Rita C Tostes, FMRP-USP
https://meet.google.com/ooe-hxxj-vxd?hs=122
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