Programação

  • Visão geral: Biologia da célula e do tecido epitelial

  • Discussão de dúvidas sobre os artigos

    Será realizado um sorteio para a apresentação dos seminários ao longo da disciplina. E será aberto para sanar dúvidas sobre os artigos a serem apresentados na próxima semana.

  • Visão geral: Epithelial cell polarity proteins as tumor suppressors e Discussão de dúvidas

  • Apresentação dos seminários 1 e 2.

    Artigo 1: McCaffrey LM, Montalbano J, Mihai C, Macara IG. Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. Cancer Cell. 2012 Nov 13;22(5):601-14. Artigo2: Andersen DS, Colombani J, Palmerini V, Chakrabandhu K, Boone E, Röthlisberger M, Toggweiler J, Basler K, Mapelli M, Hueber AO, Léopold P. The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth. Nature. 2015 Jun 25;522(7557):482-6.

  • Avaliação sobre polaridade e discussão de dúvidas sobre os artigos

  • Seminários 3 e 4

    Artigo1: Kourtidis A, Ngok SP, Pulimeno P, Feathers RW, Carpio LR, Baker TR, Carr JM, Yan IK, Borges S, Perez EA, Storz P, Copland JA, Patel T, Thompson EA, Citi S, Anastasiadis PZ. Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity. Nat Cell Biol. 2015 Sep;17(9):1145-57. Artigo2: Bogorad RL, Yin H, Zeigerer A, Nonaka H, Ruda VM, Zerial M2, Anderson DG, Koteliansky V. Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice. Nat Commun. 2014 May 21;5:3869

  • Visão geral e avaliação sobre comunicação celular

    Visão geral: Goldenring, JR. A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis. Nat Rev Cancer. 2013 Nov;13(11):813-20.

  • Seminário 5

    Artigo: Singh B, Bogatcheva G, Washington MK, Coffey RJ. Transformation of polarized epithelial cells by apical mistrafficking of epiregulin. Proc Natl Acad Sci U S A. 2013 May 28;110(22):8960-5

  • Visão geral sobre dinâmica célula-tronco epitelial e avaliação sobre tráfego intracelular

    Overview: Lineage-tracing experiments for studying epithelial stem-cell dynamics

  • Seminários 6

    Artigo 1: Wang ZA, Mitrofanova A, Bergren SK, Abate-Shen C, Cardiff RD, Califano A, Shen MM. Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity. Nat Cell Biol. 2013 Mar;15(3):274-83. 

  • 22/10- Seminário 7 e 8

    Artigo1: Hayakawa Y, Ariyama H, Stancikova J, Sakitani K, Asfaha S, Renz BW, Dubeykovskaya ZA, Shibata W, Wang H, Westphalen CB, Chen X, Takemoto Y, Kim W, et al. Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell. 2015 Dec 14;28(6):800-14. Artigo2: Snippert, HJ, Flier, LGV, Sato, T, Es JH, Born MV, et al. Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 stem cells. Cell, 143, 134-144, 2010. 

  • 24/10- Seminário 9

    Artigo: Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell. 2013 Jan 17;152(1-2):25-38.

  • 29/10- Visão geral: Plasticidade celular, EMT, e mecanismos de metástase e avaliação sobre dinâmica de célula tronco

  • 31/10- Seminário 10

    Ye X, Tam WL, Shibue T, Kaygusuz Y, Reinhardt F, Ng Eaton E, Weinberg RA. Distinct EMT programs control normal mammary stem cells and tumour-initiating cells. Nature. 2015 Sep 10;525(7568):256-60



  • 5/11- Seminário 11

    Artigo: Cheung KJ, Padmanaban V, Silvestri V, Schipper K, Cohen JD, Fairchild AN, Gorin MA, Verdone JE, Pienta KJ, Bader JS, Ewald AJ. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E854-63.


  • 7/11- Seminários 12 e 13

    Artigo1: Pattabiraman DR, Bierie B, Kober KI, Thiru P, Krall JA, Zill C, Reinhardt F, Tam WL, Weinberg RA. Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability. Science. 2016 Mar 4;351(6277):aad3680. Artigo 2: Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ. EMT Subtype Influences Epithelial Pasticity and Mode of Cell Migration. Develop Cell. 2018, 45, 681–695.




  • 12/11- Avaliação Final