Kursthemen
-
Keisa W. Mathis University of North Texas Health Science Center
Chronic inflammation has been implicated in the development of hypertension (high blood pressure). The primary focus of Dr. Mathis’s research is to understand and enhance endogenous nervous and immune system interactions that control inflammation in order to halt the progression of hypertension. To investigate this, her group uses lupus as the disease model since chronic inflammation contributes to the prevalent hypertension and renal injury in this devastating autoimmune disease that primarily affects young women.
She is currently the PI of a federally-funded grant from the National Heart, Lung, and Blood Institute. This federal grant will investigate the regulation of inflammation in the kidney that, if accumulated and left unchecked, can lead to hypertension and renal injury. Work in her lab will include integrative physiological approaches complimented with molecular, cellular, and immunological techniques. A goal of Dr. Mathis lab is to take what is learned in the mouse model of lupus hypertension and translate it into human studies that could benefit both lupus and hypertensive populations.
Paper that will be useful (attached in the e-mail also):
Pham GS, Wang, LA and Mathis KW. Pharmacological potentiation of the efferent vagus nerve attenuates blood pressure and renal injury in a murine model of systemic lupus erythematosus. AJP Regulatory. 2018; 315:R1261-R1271.