# Biossíntese de P3HB-co-3HHx a partir de glicose e ácido hexanóico considerando também a biossíntese de biomassa
# considera vias ED, PPP, CK, Glioxilato, anapleróticas e respiração aeróbia de coenzimas Considerando phaJ e cetoredutase como saídas beta-oxidação para PHA.
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-ENZREV
EMP2 EMP4 EMP5 EMP6 EMP7 EMP8 EMP9 VP6 VP7 VP8 VP9 VP10 

-ENZIRREV
EMP1 ED1 ED2 EMP10 CPD VP1 VP5 CK1 CK2 CK3 CK4 CK5 CK6 CK7 CK8 CGLX1 CGLX2 GLN3 AD1 AD2 P3HB OXFAD OXNAD BOXI1 BOXI2 BOXI3 BOXI4 BOXI5 BOXI6 BOXI7 BOXI8 BOXI9 CR01 CR02 PHAJ1 PHAJ2 SDH PNTAB BIOM

-METINT
G6P KDPG2 NADP NADPH PG6 PIR G3P BPG13 PG3 PG2 PEP AcCoA Rbl5P Rb5P X5P S7P E4P F6P DHP F16P OAA Cit KG2 IsoCit SucCoA Suc Fum Mal GLX FAD FADH2 NAD NADH CoASH HexCoA HexenCoA HHexCOA CHexCoA ButCoA ButenCoA HButCoA CButCoA 

-METEXT
Gliex Hexext ADP ATP CO2 O 3HB 3HHx XR  

-CAT
EMP1 : Gliex + ATP = G6P + ADP .
EMP2 : G6P = F6P .
VP1 : G6P + NADP = PG6 + NADPH .
ED1 : PG6 = KDPG2 .
ED2 : KDPG2 = PIR + G3P .
EMP4 : F16P = G3P + DHP .
EMP5 : DHP = G3P .
EMP6 : G3P + NAD = BPG13 + NADH .
EMP7 : BPG13 + ADP = PG3 + ATP .
EMP8 : PG3 = PG2 .
EMP9 : PG2 = PEP .
EMP10 : PEP + ADP = PIR + ATP .
CPD : PIR + NAD + CoASH = AcCoA + NADH + CO2 .
VP5 : PG6 + NADP = NADPH + Rbl5P + CO2 .
VP6 : Rbl5P = Rb5P .
VP7 : Rbl5P = X5P .
VP8 : Rb5P + X5P = S7P + G3P .
VP9 : G3P + S7P = E4P + F6P .
VP10 : X5P + E4P = F6P + G3P .
CK1 : OAA + AcCoA = Cit + CoASH .
CK2 : Cit = IsoCit .
CK3 : IsoCit + NADP = KG2 + NADPH + CO2 .
CK4 : KG2 + NAD + CoASH = SucCoA + NADH + CO2 .
CK5 : SucCoA + ADP = Suc + ATP + CoASH .
CK6 : Suc + FAD = Fum + FADH2 .
CK7 : Fum = Mal .
CK8 : Mal + NAD = OAA + NADH .
CGLX1 : IsoCit = GLX + Suc .
CGLX2 : GLX + AcCoA = Mal + CoASH .
GLN3 : F16P = F6P .
AD1 : PIR + CO2 + ATP = OAA + ADP .
AD2 : OAA + ATP = PEP + ADP + CO2 .
P3HB : 2 AcCoA + 1 NADPH = 3HB + 2 CoASH + 1 NADP .
OXFAD : FADH2 + 2 ADP + O = FAD + 2 ATP .
OXNAD : NADH + 3 ADP + O = NAD + 3 ATP .
BOXI1 : Hexext + 2 ATP + CoASH = HexCoA + 2 ADP . 
BOXI2 : HexCoA + NAD = HexenCoA + NADH . 
BOXI3 : HexenCoA = HHexCOA .
BOXI4 : HHexCOA + NAD = CHexCoA + NADH .
BOXI5 : CHexCoA + CoASH = ButCoA + AcCoA .
BOXI6 : ButCoA + NAD = ButenCoA + NADH . 
BOXI7 : ButenCoA = HButCoA . 
BOXI8 : HButCoA + NAD = CButCoA + NADH .
BOXI9 : CButCoA + CoASH = 2 AcCoA .
CR01 : CHexCoA + NADPH = 3HHx + NADP + CoASH .
CR02 : CButCoA + NADPH = 3HB + NADP + CoASH .
PHAJ1 : ButenCoA = 3HB + CoASH .
PHAJ2 : HexenCoA = 3HHx + CoASH .
BIOM : 205 G6P + 71 F6P + 897 Rb5P + 361 E4P + 129 G3P + 1496 PG3 + 519 PEP + 2833 PIR + 3748 AcCoA + 1079 KG2 + 1787 OAA + 3547 NAD + 18225 NADPH + 18485 ATP = 10000 XR + 18485 ADP + 3547 NADH + 18225 NADP + 3748 CoASH .
SDH : NADPH + NAD = NADP + NADH .
PNTAB : NADH + ATP + NADP = NAD + ADP + NADPH .